Department head/Associate Professor US Army Institute of Surgical Research/Texas A&M UNiversity San Antonio, Texas, United States
Disclosure(s):
Thomas Edwards, DVM, MS, DACVECC: No financial relationships to disclose
Presentation Description / Summary: The inflammatory and coagulation systems do not exist in isolation. Rather there is a dynamic relationship between the two systems whereby proinflammatory mediators activate and propagate the coagulation system. Conversely, anti-inflammatory signals also impact the coagulation system, modulating thrombus formation and/or fibrinolysis. A wide variety of signaling proteins within the body have significant effects on both the inflammatory and coagulation systems to include activated protein C, thrombin, complement and tissue factor. Furthermore, platelet activation and the fibrinolytic system are not just controlled by traditional coagulation signals but are also influenced by the degree of inflammation in the body. The interplay between these two systems will be covered in depth during this lecture. This knowledge is essential for the advanced clinicians when trying to maximize outcomes in complex patients with SIRS, sepsis or coagulopathies.
Learner Outcomes: Learning objective 1: Understand the cellular mechanisms that influence and regulate coagulation and how they impact inflammation. Learning Objective 2: Understand the cellular mechanisms that influence and regulate inflammation and how they impact coagulation.
Learning Objectives:
Upon completion, participant will be able to understand the cellular mechanisms that influence and regulate coagulation and how they impact inflammation.
Upon completion, participant will be able to understand the cellular mechanisms that influence and regulate inflammation and how they impact coagulation.
