Professor University of Missouri Columbia, Missouri, United States
Disclosure(s):
Carol R. Reinero, DACVIM PhD: No relevant disclosure to display
Presentation Description / Summary: Study in experimental and spontaneous feline asthma models aids in understanding the immune drivers in this disease, and in discovering novel means of treatment. Allergic asthma is considered a Type 2 (T2) high inflammatory process triggered by aeroallergens centered in the respiratory tract. T helper cells play a key role in cytokine production, leading to airway eosinophilia and contributing to airway hyperresponsiveness and airway remodeling. Investigations of novel immune-based therapies including adipose derived mesenchymal stem cells, tyrosine kinase inhibitors, and monoclonal antibody therapy in experimental feline asthma will be discussed.
Learning Objectives:
To understand general respiratory immunology concepts as they relate to pathogenesis of feline allergic asthma
To learn different types of immune-based therapies relevant to feline allergic asthma
To understand how immune-based therapies modulate the pathogenic features of feline asthma
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