Associate Professor University of Tennessee Knoxville, Tennessee, United States
Disclosure(s):
Paolo Pazzi, BVSc, MMedVet, Dip ECVIM (Internal Medicine), PhD: No financial relationships to disclose
Presentation Description / Summary: Normal hemostasis, assessment of hemostatic abnormalities, and the etiology of hemostatic abnormalities in tumor-bearing dogs will be briefly reviewed. Evidence of hemostatic abnormalities in common canine tumors, the prevalence of thromboembolic disease, and the classification of tumor-bearing dogs as a population at risk for thromboembolic disease will be evaluated. The possible contribution and role of hypercoagulability and microthrombi in the development and detection of metastasis will be discussed. Finally, proposed studies utilizing antithrombotics to reduce thrombotic disease, tumor growth and metastases will be presented.
Learning Objectives:
Explain the key factors contributing to, and the consequences of an altered hemostatic state in tumor-bearing dogs.
Briefly describe the prevalence and relevance of macro- and micro-thromboembolic disease in tumor-bearing dogs.
Explain how manipulation of the hemostatic pathway may reduce tumor growth and metastasis.
