Executive Vice President Fred Hutch Cancer Center Seattke, Washington, United States
Disclosure(s):
Fred Appelbaum, MD: No financial relationships to disclose
In this session, Dr. Appelbaum will discuss how the development of marrow transplantation has led to a variety of revolutionary new therapies. Marrow transplantation demonstrated that it was possible to cure various genetic diseases of the blood, including sickle cell anemia and thalassemia, by replacing an abnormal marrow with a normal one, thus setting the stage for today’s gene therapies. Transplantation was the first demonstration of the power of the human immune system to eradicate malignancy, directly leading to today’s CAR-T cell and other immunotherapies. And transplantation showed that it was possible to create life-long tolerance without the need for continued immunosuppression, leading to new approaches to solid organ transplantation. Continued progress will require continued collaborations between government, academia, and biopharma.
Learning Objectives:
Identify the major new therapies built upon the principals of marrow transplantation
Understand how these new therapies will be further developed
Consider the major threats to further progress in these areas
