Graduate student Laboratory of Internal Medicine, College of Veterinary Medicine and Research Institute for Veterinary Science, Seoul National University Ansan, Kyonggi-do, Republic of Korea
Abstract:
Background: In veterinary medicine, the use of high-flow nasal cannula (HFNC) has been increasing, but research data on the efficacy of HFNC in treating non-cardiogenic pulmonary edema (NCPE) remains limited.
Hypothesis/
Objectives: To determine whether HFNC is more effective than conventional oxygen therapy (COT) in managing dogs with NCPE, based on respiratory rate (RR), peripheral capillary oxygen saturation (SpO2), dyspnea scores, and survival rate.
Animals: Twenty-six client-owned dogs diagnosed with NCPE and treated with either COT or HFNC.
Methods: Retrospective case series. Medical records were searched from September 2022 to September 2024. Dogs were divided into two treatment groups: COT (n=13) and HFNC (n=13). Changes in RR, SpO2 and dyspnea scores were obtained at the pre- and post-treatment. The data gathered in this study were compared using non-parametric tests as the Wilcoxon signed rank test and the Mann Whitney U test at a significance level of p < 0.05.
Results: Both COT and HFNC lead to improvement of RR and SpO2, but significantly higher enhancement in HFNC (p < 0.05). Additionally, the dyspnea scores significantly decreased only in the HFNC group (p < 0.01). There were no surviving patients in COT group, whereas 2 patients in HFNC group were alive at the end of the study. There were no serious adverse events associated with the use of HFNC, except for two cases of aerophagia.
Conclusions and clinical importance: HFNC can be a life-saving tool compared to COT, resulting in improvements in respiratory parameters (RR, SpO2, and dyspnea score) in dogs with NCPE.