Associate Professor Department of Large Animal Sciences DK-2630 Taastrup, Hovedstaden, Denmark
Disclosure(s):
Sanni Hansen, DVM, PhD, DECEIM: No financial relationships to disclose
Presentation Description / Summary: Key factors in equine asthma pathogenesis include immune dysregulation, ongoing bronchoalveolar lavage neutrophilia, and redox imbalance. Inhalation of environmental allergens causes airway inflammation and the production of reactive oxygen species. Antioxidants can partly counterbalance oxidative stress. The aim of this presentation is to give an overview of existing knowledge about redox imbalance and equine asthma, and to add with some new knowledge from a recent study including measurement of new antioxidant markers investigated both systemically as well as local in the tracheal wash and the bronchoalveolar lavage.
Learning Objectives:
Identify and describe the key oxidative stress biomarkers involved in the pathogenesis of equine asthma.
Interpret diagnostic findings, including oxidative stress markers, bronchoalveolar lavage fluid (BALF) cytology, and inflammatory cytokine profiles, to assess redox status in asthmatic horses.
Critically appraise current research with focus on the efficacy of antioxidant and anti-inflammatory interventions in managing redox imbalance in equine asthma.
