Nephrology, Urology, and Extracorporeal Therapies Friendship Hospital for Animals Washington, District of Columbia, United States
Disclosure(s):
JD Foster, VMD, MS, DACVIM (SAIM), DACVCP: No relevant disclosure to display
Presentation Description / Summary: This lecture explores the multifaceted reasons behind antibiotic therapy failure in patients with kidney disease, emphasizing the unique challenges posed by impaired renal function. It delves into the pharmacokinetics of antibiotics in the context of reduced kidney function, highlighting how altered drug metabolism and excretion can lead to suboptimal drug levels and therapeutic outcomes. Additionally, the lecture will provide strategies for optimizing antibiotic use in kidney disease patients, aiming to improve treatment efficacy and patient outcomes.
Learner Outcomes: 1. Understand the altered antibiotic pharmacokinetics that occur in kidney disease and how to adjust the prescription to increase the likelihood of effective drug therapy. 2. Review the specific challenges in pyelonephritis towards achieving successful microbial eradication. 3. Learning which scenarios where urine culture susceptibility reports may not accurately reflect the likelihood of successful antibiotic therapy.
Learning Objectives:
Upon completion, participant will be able to understand the changes to drug pharmacokinetics that may restut in ineffective antimicrobial therapy.
Upon completion, participant will be able to identify drugs whose pharmacology may be more affected by states of decreased kidney function.
Upon completion, participant will be able to gain tools to design more effective antibiotic dosing strategies to treat infections in patients with kidney disease.
