Senior Veterinary Pathologist & Clinical Associate Professor University of New Hampshire Durham, New Hampshire, United States
Disclosure(s):
David B. Needle, DVM, DACVP: No financial relationships to disclose
Presentation Description / Summary: The lecture will begin with a discussion of the respiratory tract anatomy and innate immunity, then a review of the known components of the canine infectious respiratory disease complex (CIRD). This will be followed by details of the investigation and findings from our work characterizing a potential novel CIRD component that began as a local uptick in CIRD-like disease in southern NH. This syndrome was clinically consistnet with CIRD, but refractory to empirical treatment and had a longer duration. The syndrome subsequently emerged regionally and then nationally, which will be outlined. We will dedicate some time to discussing the sequencing and informatic tools utilized in this study, from a general standpoint, and then specifically as they were applied. The talk will conclude with details of this potential pathogen, the bacterium to which it is most closely related, and findings of molecular and genomic analysis of all the samples received in the study.
Learning Objectives:
Review respiratory tract anatomy and innate immune functions and known CIRD components.
Understand the options for testing in a emerging disease investigation, specifically the modalities to investigate suspected infectious diseases.
Learn about the potential pathogen we have identified, including distribution, comparative genomics, and functional genomics.
