Professor Mississippi State University Starkville, Mississippi, United States
Disclosure(s):
Amelia R. Woolums, DVM PhD DACVIM DACVM: No relevant disclosure to display
Presentation Description / Summary: A case can be made that the lungs are the bovine Achilles' heel. While cattle can deal with a variety of difficulties and insults, respiratory disease is the most common cause of sickness and death in U.S. cattle. Immune memory leading to rapid production of mucosal antibody can protect cattle from viral respiratory infection. Serum neutralizing antibodies and cell-mediated immunity also provide protection against respiratory infection. While bovine respiratory disease is often blamed on immunodeficiency, emerging evidence suggests that excessive inflammation, possibly mediated by inadequate or poorly timed expression of specific pro-resolving mediators (SPM), may be the leading precipitator of bovine respiratory disease in at least some cases. Evidence for these new concepts will be presented, with discussion encouraged.
Learner Outcomes: 1. Attendees will learn the components of the mucosal, humoral, and cell-mediated immune responses that have been linked to protection against bovine respiratory infection. 2. Attendees will learn the scientific evidence that excessive inflammation, rather than immunodeficiency, is the primary driver of severe bovine respiratory disease. 3. Attendees will learn about the classes of specific pro-resolving mediators, and the evidence that these mediators play a role in limiting bovine respiratory disease.
Learning Objectives:
Upon completion, participant will be able to describe the components of the mucosal, humoral, and cell-mediated immune responses that have been linked to protection against bovine respiratory infection.
Upon completion, participant will be able to describe the scientific evidence that excessive inflammation, rather than immunodeficiency, is the primary driver of severe bovine respiratory disease.
Upon completion, participant will be able to recognize the classes of specific pro-resolving mediators, and the evidence that these mediators play a role in limiting bovine respiratory disease.
